DSM-5-TR Handbook of Differential Diagnosis

By Michael B. First

DSM-5-TR Handbook of Differential Diagnosis is the authoritative clinical companion to the DSM-5-TR, designed to strengthen diagnostic accuracy in mental health practice. Written by Michael B. First, a key contributor to the DSM-5-TR, this handbook provides a systematic, step-by-step framework for distinguishing between psychiatric disorders with overlapping symptoms.

Widely used by psychiatrists, psychologists, and trainees, the handbook translates DSM-5-TR criteria into practical diagnostic decision-making tools. It emphasizes real-world clinical reasoning, cultural context, and evolving diagnostic practices, including telepsychiatry.

What This Handbook Does

This book guides clinicians through the differential diagnosis process using structured decision trees, symptom comparisons, and case-based reasoning. It helps practitioners avoid common diagnostic errors and apply DSM-5-TR criteria accurately across diverse clinical settings.

Key Features

• Systematic differential diagnosis aligned with DSM-5-TR criteria
• Clear diagnostic decision trees and comparison tables
• Clinical guidance for complex and overlapping symptom presentations
• Coverage of cultural, contextual, and substance-related factors
• Updated perspectives on telepsychiatry and digital diagnostic tools

Topics Covered

• Principles of Differential Diagnosis
• DSM-5-TR Diagnostic Criteria Overview
• Symptom-Based Diagnostic Decision Trees
• Mood, Anxiety, and Trauma-Related Disorders
• Psychotic and Neurodevelopmental Disorders
• Substance-Related and Addictive Disorders
• Cultural and Contextual Diagnostic Considerations
• Case Studies and Clinical Applications

The essential guide to accurate psychiatric diagnosis using DSM-5-TR.
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